Clinical pharmacokinetics according to administration route of mitomycin C and determination of mitomycin C in body fluids by HPLC.
نویسندگان
چکیده
منابع مشابه
Pharmacokinetics of Intraarterial Mitomycin C in Humans1
The pharmacological advantage of mitomycin C (MMC) given by intraarterial infusion as compared to i.v. infusion was studied in seven patients with cancer metastatic to the liver. Hepatic artery, hepatic vein, and peripheral vein catheters were placed, and then each patient received constant infusions of MMC via the intraarterial and peripheral i.v. routes at 0.4,1.2, and 4.0 mg/ sq m/hr. MMC co...
متن کاملEfficacy of Intraoperative Mitomycin-C in Vasovasostomy Procedure: A Randomized Clinical Trial
Objective Background: 2% to 6% of vasectomized men will ultimately seek vasectomy reversal and late stricture and obstruction after operation are relatively common. Objective: To find a method for improving of vasovasostomy outcomes, we used intra-operative local mitomycin-C to prevent possible fibrosis and stricture. MaterialsAndMethods Design, setting, and participants: 44 patients in our ref...
متن کاملHyperthermic enhancement of cell killing by mitomycin C in mitomycin C-resistant Chinese hamster ovary cells.
The interaction of hyperthermia and mitomycin C (MMC) was studied in wild-type Chinese hamster ovary cells and in Chinese hamster ovary cells selected for resistance to MMC. Hyperthermic potentiation of MMC activity was maximal if heating was done simultaneously, or up to 3 h following MMC exposure. Heat enhanced the effect of MMC in both drug-sensitive and -resistant cells. Dose enhancement ra...
متن کاملPharmacokinetics of intravesical mitomycin C in superficial bladder cancer patients.
Intravesical mitomycin C (MMC) therapy is used to treat superficial bladder cancer. This study was to establish the intra- and intersubject variabilities in the systemic (plasma) and target site (bladder) exposure to the drug and to identify the factors which contribute to these variabilities. The pharmacokinetics of MMC were studied in 10 patients. Treatment consisted of transurethral tumor re...
متن کاملPharmacokinetics of Mitomycin C Following Hepatic Arterial Chemoembolization With Gelfoam
Twelve mongrel dogs were randomly allocated into two groups using matched paired-design. Catheters were inserted into the hepatic artery, hepatic vein and the femoral vein, respectively. In the first group, gelfoam supplemented with mitomycin C (MMC) was injected into the hepatic artery, whereas the second group received a hepatic arterial injection of MMC solution alone. Simultaneous blood sam...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics
سال: 1987
ISSN: 1882-8272,0388-1601
DOI: 10.3999/jscpt.18.141